Deep in the Brazilian Rainforest, a river barge makes its way up the Amazon. Aboard is a documentary film crew with a dream assignment: to track down the legendary Shirishama Indians-- the people of the Mist! But during a violent storm, the crew rescues a mysterious stranger, Paul Sarone (Jon Voight), whose boat has stalled on the river. Charismatic and charming, Sarone professes a vast knowledge of the Shirishama and volunteers to lead the filmmakers directly to the elusive tribe. But the manipulative Sarone is actually a poacher in pursuit of his own mad dream: a lethal 40-foot anaconda, the largest and most vicious killer snake in the world! And so begins a terrifying journey into a nightmare as Sarone literally leads his unwilling followers into the jaws of death... an adventure few will live to tell.