When a deranged, childless couple -- the schizophrenic Helen (Jennifer Tilly) and her fertility doctor husband, Frank (Vincent Gallo) -- kidnap a wealthy pregnant woman named Anne (Daryl Hannah), the woman's husband (Bruce Greenwood) tries to save her. But his hopes plummet when the conniving couple leads him to believe she's dead. Meanwhile, Anne endures abuse while chained to a bed in this dark and chilling thriller.