In Resident Evil: Afterlife, Alice (Milla Jovovich) manages to infiltrate the secret underground headquarters of the Corporation. The man in charge, Albert Wesker (Shawn Roberts), escapes and blows up the entire compound. He also manages to inject Alice with a serum that will destroy her superpowers and make her human again. She resolves to find more survivors, following a rescue signal. She runs into her old friend, Claire (Ali Larter), and then finds a bunch of humans trapped inside an empty prison building in Los Angeles. They discover that the signal is coming from a ship just off the coast, but how can eight humans get out of a building totally surrounded by hordes of the undead? And even if they do, how do they know the ship is really safe?