Stuck On You centers on Bob (Matt Damon) and Walt (Greg Kinner) Tenor, conjoined twins who own a small restaurant on Martha's Vineyard. Bob is the shy one who is carrying on an email romance with a girl in California. Walt is the outgoing ladies' man who wants to be an actor. Following a triumph in his production of \"Tru,\" the one-man show about Truman Capote, he tells Bob he wants to go to Los Angeles to try to make it as an actor. Soon they are installed in the Rising Star apartments and Walt is meeting with agents and going on auditions. They run into a couple of celebrities, including Cher and Meryl Streep. Cher decides that the best thing she can do to get out of a contract to star in an idiotic television series about a lawyer/investigator team called \"Honey and the Beeze,\" is to exercise her right to select her leading man by insisting on Walt. Meanwhile, Bob has finally met his email-pal in person, but has kept the special nature of his relationship with Walt a secret.