Condemned warlock Joseph Curwen (Vincent Price) curses a New England village just before being burned alive. More than a century later, Curwen's kindly great-great grandson Charles Ward (also Price) arrives in town and moves into Curwen's old mansion. Caretaker Simon Orne (Lon Chaney Jr.) helps Charles and his wife Ann (Debra Paget) adjust to their new home. The ancient curse, however, takes hold of Joseph, awakening inside him a long-dormant evil passed on through blood.