In 1964, Dr. David Henry (Dermot Mulroney) separated his daughter from her twin brother to hide the daughter's Down Syndrome from his wife. Entrusting the baby to a nurse (Emily Watson), David cut off all contact to focus on his wife (Gretchen Mol) and his son. Over the next 25 years, his disabled daughter grows into a beautiful adult while David watches the rest of his family fall apart, knowing he can never reveal his darkest secret.