In 1947 Hollywood, Eddie Valiant (Bob Hoskins), a down-on-his-luck detective, is hired to find proof that Marvin Acme, gag factory mogul and owner of Toontown, is playing hanky-panky with femme fatale Jessica Rabbit, wife of Maroon Cartoon superstar Roger Rabbit. When Acme is found murdered, all fingers point to Roger, and the sinister, power-hungry Judge Doom (Christopher Lloyd) is on a mission to bring Roger to justice. Roger begs the Toon-hating Valiant to find the real evildoer and the plot thickens as Eddie uncovers scandal after scandal and realizes the very existence of Toontown is at stake!