When the team treats a 6-year-old with multiple health issues, they must collaborate with her mother (Jessica Collins), who is also a doctor; Wilson and House go on vacation.
In an upstairs/downstairs-type investigation, the CSIs look into solving two forensic mysteries: the first, the murder of a rising young movie star, amongst his entourage of best friend slackers and groupies, in his hotel suite. In the second story, the immigrant Laotian kitchen workers in the hotel may have turned against each other and committed murder. (TV-14 D)
David and Keith continue trying to iron out their problems...and Karla has a secret that isn't going to make things any better. Meanwhile, Claire takes a curious approach to photography, Ruth prepares to move ahead with Nikolai and Brenda's engagement anxiety leads her on a sexual adventure with Melissa.
When a judge's wife is shot and killed, Don and his team look into the judge's cases to determine if one of his verdicts led to the murder. Using the judge's past rulings and Megan's expertise in profiling, Charlie creates a mathematical theory to identify the two most probable suspects from the case files. However, when the team discovers a link between the two suspects, the investigation goes in an unexpected direction.
Paul recruits Denise to help him defend a cancer patient who used his wealth to guarantee he would not get a placebo during a drug study. Meanwhile, Alan goes too far in trying to convince the senior partners to promote "Hands" to partner, and Denny finds himself falling in love with a woman he meets at a charity event.
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