Without the help of a team, House scrambles to diagnose a woman after a building collapses on her on the season premiere of "House".
The aftermath of the school shooting forces the residents of Tree Hill to examine their lives. Nathan reassesses his relationship with Haley, while Brooke and Rachel (recurring guest star Danneel Harris) join forces to heal the student body. Dan must deal with the ramifications of shooting Keith. And Lucas and Peyton consider the implications of their kiss in the library.
Brooke organizes a beach party to celebrate the end of summer but soon finds she's the only one in a party mood. Nathan comes home to reconnect with Haley, but now he and Lucas aren't getting along. Meanwhile, Lucas struggles with Brooke's new rules for dating, and Peyton tries to come to terms with the newly discovered secrets about her family. Finally, Dan remembers what happened the night of the fire at his dealership.
Lucas and Peyton take a road trip together to find Ellie (recurring guest star Sheryl Lee). While out of town, Lucas reconnects with a friend from his past. Brooke, Haley and Mouth successfully launch the Clothes Over Bro's web site, only to find that demand far exceeds supply. Deb reveals to Nathan that she tried to kill Dan.
As the town readies for the Ravens' first basketball game, Lucas worries about his lack of commitment to basketball. Nathan accuses Lucas of being the team's weakest link. Peyton and Haley ignore past differences to support Brooke in a time of need. When the mayoral race tightens, Dan resorts to a smear campaign.
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