Mel engages in a tense family reunion when she and her disapproving sister (Camilla Mana) race against the clock to save their brother Edison after he's abducted.
Abruzzi, Sucre and C-Note make a run for it on their own; Michael and Lincoln plan another breakout – this time to rescue a jailed LJ, whom Mahone targets in his quest to capture the escaped cons; Bellick and Warden Pope face a jury of their peers regarding the prison escape; Tweener hitches a ride with the college crowd; and T-Bag takes drastic measures to get the upper hand.
The Rangers are stumped by a series of highly publicized, multi-million dollar robberies by men in clown masks, but the investigation becomes personal when Walker's close friend, Ranger Logan Reno, is killed.
Coach Taylor (Kyle Chandler) is offered a deal he can't refuse and Tim (guest star Taylor Kitsch) assesses his future plans when an old flame returns to Dillon. Meanwhile, the fate of East Dillon's football program is decided.
Walker must help track down a wrongly jailed man after he escapes from the prison guards who are trying to kill him.