In the aftermath of a deadly plane crash, Bobby and team race to help the survivors, while Athena deals with panic and chaos at the airport. Bobby confronts his past demons; Athena is out for revenge against a group of teen bullies; and Abby delivers an important message from a 9-1-1 caller.
Brennan and Booth investigate the body of a man murdered for the undisclosed contents of a briefcase. Early evidence leads the team to suspect secret operatives are at work, and their theories are supported when the liquefied remains of a CIA agent are discovered in the trunk of a car. When Brennan and Booth interrogate the CIA's Assistant Director of Intelligence, they are left unsure of his allegiance to the U.S. Meanwhile, Brennan's best-selling book leads to financial success and serves as a point of contention with Booth, and Jeffersonian intern Wendell (guest star Michael Grant Terry) loses his scholarship, leaving the team to look for alternative funding to keep him around.
Chastain picks up the pieces after breaking ties with the corrupt medical device company Quovadis, leaving Marshall ready to charter new territory in the medical field, and Devon to finally discover the truth about what happened to Julian Booth.
Intelligence investigates some armed bank robberies, which point to some surprising suspects.
When the hospital has a severe blood shortage, Conrad must try every avenue to save a patient’s life. Nic receives devastating news and is left worrying about her sister’s health, while Mina and Devon work with a new anesthesiologist who is not what she seems. Elsewhere, Kit considers the future of her intertwining relationships and Bell has an encounter with a woman from his past.
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