While at an out-of-town forensic pathology convention, Rosewood unintentionally reveals the blueprint to commit the perfect murder during a speech to the convention attendees. Tormented, and armed only with a hunch, Rosewood enlists Villa to help solve the crime, and while investigating undercover, sparks fly unexpectedly between them. Hornstock and Floyd Butters are called upon for extra help. Meanwhile, Pippy and TMI have locked themselves in the lab overnight to help with the investigation and TMI receives an unexpected visit from her estranged father.
Nick (David Giuntoli) and Hank (Russell Hornsby) are called to an unusual crime scene with a victim who appears to have died from clay-induced asphyxiation. At the precinct, Wu (Reggie Lee) begins to grow more suspicious of Trubel’s (guest star Jacqueline Toboni ) presence. At the Spice Shop, Elizabeth (guest star Louise Lombard) makes a major breakthrough with regards to restoring Nick’s powers, while Monroe (Silas Weir Mitchell) and Rosalee (Bree Turner) experience cultural backlash as a result of their inter-Wesen marriage. In Europe, Adalind (Claire Coffee) hopes that putting trust in her mysterious visitor will help her escape the dungeon.
When Ned's Occult Anthropology professor is stalked by the ghost of a secret admirer, a Ouija board is used to try and solve the mystery but instead creates a new one that threatens a life.
Sqweegel, a serial killer who is punishing local heroes that harbor hidden secrets, is on the hunt in Las Vegas.
A gunpoint abduction at a doctors office puts Team One on a collision course with a desperate felon as his bleeding sons life rests in Sam's hands.
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