A drunken Chandler fools around with one of Joey's sisters--but he can't remember which one.
The chaos of an urban, public hospital emergency room and the lives of its devoted doctors and staff, a Chicago building collapses, and everyone in the ER must overcome personal dramas to save lives.
A teenage girl is brought to the hospital with severely swollen appendages after a wild night out; as her condition worsens, the patient is unable to distinguish fact from fiction; the doctors attend a medical conference.
Pete, Violet, Sam and Addison adjust to their new lives; Addison second-guesses her desire for a baby; Violet thinks about dating a paramedic.
While Brian recuperates from an injury, he becomes jealous when Alex spends time with Joe.