Captain Mal and his crew are hired to hijack a train, but the situation gets even more complicated when a medicine theft operation aimed at helping a population stricken with a fatal disease is uncovered.
The crew comes across an abandoned ship of dead aliens.
When Archer and his crew pay a friendly visit to an ancient Vulcan monastery, they stumble into an interstellar conflict between the Vulcans and their militaristic rivals, the Andorians.
Grissom and crew are called in after high roller Tony Braun, a known drug addict, is found dead in his house by a gardener.
Disguised as medical personnel, the crew infiltrates a hospital with the intention of stealing valuable supplies; meanwhile, Simon uses a high-tech imaging device to study River’s brain in hopes of curing her…only to be betrayed by Jayne.