Andre forms a new musical relationship with Michelle, and a woman from Lucious’ past, Angie, comes into the picture. Meanwhile, Lucious invites the whole family over to his home. However, everyone arrives with their own agendas. Hakeem, under the influence of Camilla, sets out to show his father that he’s a true artist and a good businessman. Then, Cookie prepares to state her own agenda for Empire and for her family, when Olivia arrives .
Crockett and Blake clash with Randall when a famous alcoholic football player needs a liver transplant. Dylan is reluctantly reunited with old friends when their son breaks his arm. Stevie and Charles work together when a patient falls ill after back-alley plastic surgery.
Will and Stevie get stuck in the middle of a marital face-off. Dr. Blake's entire surgical team mysteriously collapses during a liver transplant. Charles encourages Ethan to reconcile with his father.
Goodwin assigns Med's new compliance officer to a patient with a long-hauler Covid condition. Maggie helps Will treat a patient who's been in an iron lung for 60 years. Stevie learns hard truths about her mother. Terrell returns to Med under dire circumstances.
Dr. Rhodes (Colin Donnell) and Dr. Charles' (Oliver Platt) heart transplant patient gets into a car crash, revealing issues that could complicate her surgery. A past arrest causes trouble for Maggie (Marlyne Barrett) when the arresting officer is brought to Chicago Med with a serious injury. Elsewhere, Dr. Manning (Torrey DeVitto) and Dr. Halstead (Nick Gehlfuss) must defend their actions when explaining a patient's cause of death. Meanwhile, Dr. Halstead attempts to treat an uncooperative horse jockey. S. Epatha Merkerson, Yaya DaCosta, Brian Tee and Rachel DiPillo also star. Kara Killmer, Amy Morton, Ato Essandoh and Eddie Jemison guest star.
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