John S. Davies

The season opener finds Michael Scofield in Sona, a hellish and deadly Panamanian prison where a previous riot has forced all authority out and has left the prisoners in charge of their own lives (and deaths). With the fate of his loved ones hanging in the balance, Michael must to find Whistler, a mysterious fellow inmate hiding within the prison's sewer system, in order to break him out from a prison from which there is no way out. Meanwhile, Lincoln searches for a missing Sara and receives troubling news about LJ.

Michael races against the clock to rescue Lincoln and beat Mahone at his own end game; Sucre risks his life to save a missing Maricruz; Kellerman's testimony at Sara's trial proves deadly; and T-Bag and Bellick find themselves up a Panamanian river.

Walker fears he may have to take down an old friend in town from Japan, knowing the man has ties to the Japanese mob.

When an inmate is found murdered, Whistler becomes the prime suspect and Michael must prove his innocence in order to save his life; Michael demands evidence from Susan that Sara is alive, or he will cancel the escape; Lincoln and Sofia monitor the guards' morning rituals; Mahone gets an offer that may get him a ticket out of Sona in this special two-part episode.

Susan takes the escape into her own hands, leaving Michael's life hanging in the balance; Lechero reveals a secret buried beneath Sona; Sofia uncovers more of Whistler's past; Mahone's freedom hinges on his testimony; and Lincoln and Sucre are targeted by The Company.

Kurt Nypo, a powerful drug dealer, is attempting to get rid of Walker when he starts to get close. Nypo also has Tony Kingston, one of Walker's karate students (and whose mom he is dating), deliver the drugs. Meanwhile, the Rangers are working on locating a rapist at a college that Alex teaches at.