Brennan and Booth are called to the scene of a deadly fire at a D.C. prison to investigate what they believe is the death of Brennan's incarcerated adversary, serial killer Howard Epps, whose body was found burned beyond recognition. But Brennan's examination leads to the chilling realization that the charred body is not Epps', but that of a D.C. fireman Epps killed in order to fake his own death and escape from a maximum security prison amid the commotion of the fire. After paying a visit to Epps' former wife, Caroline, to determine if she has any clue as to his whereabouts, Brennan and Booth leave empty-handed, but are concerned for Caroline's safety with her ex-husband on the loose. Their fears are quickly realized as they get concrete proof that Epps has killed again. As Epps leads Brennan and Booth into a game of cat and mouse, it's clear he is targeting them and the people they're close to, all the while giving them clues they desperately try to decipher before Epps takes another victim. While Cam conducts an autopsy on Epps' latest victim, Booth implores her to break protocol to save time and jump to a later step in the process. Against her better judgment she does, but she is sprayed with a deadly poison and critically injured. As Cam's life hangs in the balance, Booth, Brennan and the rest of the Jeffersonian team race to figure out what deadly substance is killing Cam and determine Epps' whereabouts before Cam becomes his latest victim.
Whitney and Katie defend an ex-cop charged with murder, but are shocked to find that the main piece of evidence is an MRI of his brain that "proves" he is a racist. Alan defends Denny in court when he is charged with wrongful termination after firing an associate for being too fat. Meanwhile, Carl is furious when once again Clarence is caught on YouTube in drag, and Jerry is nervous about taking his new relationship with Leigh to the next level.
Dr. Sean McNamara (series star Dylan Walsh) and Dr. Christian Troy (series star Julian McMahon) are plastic surgeons, best friends and business partners who run McNamara/Troy, a prominent South Beach practice. A seemingly conservative family man, Sean has come to realize that his financial success and perfect home can no longer mask the problems of his marriage. On the other hand, single and often promiscuous Christian has few inhibitions and enjoys the benefits of his lucrative career and good looks, even as he yearns to have a family of his own. Sean's marriage to disillusioned Julia (series star Joely Richardson) is crumbling, and his relationship with his 18-year-old son, Matt (series star John Hensley--not appearing in this episode), is troubled and tense. Dr. Liz Cruz (series star Roma Maffia) is the team's opinionated anesthesiologist.
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