Phoebe begins dating a guy who works for Monica, causing a problem when Phoebe wants to dump him on the same day Monica plans to fire him. Ross discovers that a coworker of Chandler's has been calling him Toby for five years. Joey sets Rachel up on a date with one of his co-stars. Ross worries about this and the fact that he doesn't see a future with Rachel anymore.
Five years into the future - Susan tries to hide her relationship with a new man, Bree is set to publish a cookbook and Lynette catches her teenage twins engaging in illegal activities.
Carlos walks out on his relationship with Edie; Susan finds Mike's supposedly dead father; an unexpected delivery at a Halloween party surprises the neighborhood.
After Katherine announces that she has to leave town, Bree is left responsible for catering Bob and Lee's wedding. Gabrielle finds $118,000 in Ellie's teddy bear. Susan realizes she will soon lose someone she loves. Katherine Mayfair's secrets are finally revealed, and several residents of Wisteria Lane are faced with deadly threats.
Edie receives shocking news at the gynecologist's office; an unexpected visitor; Wisteria Lane welcomes new neighbors who happen to be partners.