After tracking stolen Navy TNT to a cocaine warehouse, Special Agent Pride and the NCIS team uncovers a domestic drug ring that is producing their own cocaine and headed by Sonja's childhood friend, Marion Watkins (Samaire Armstrong).
When the top salesperson for a beauty company/pyramid scheme is murdered, Five-0 sifts through a long list of possible suspects who would want her dead. Also, Adam befriends a homeless man estranged from his family.
A drug bust-turned-shootout tests the bravery of the doctors of Angels Memorial as they race to save a girl caught in the crossfire. Also, Willis (Rob Lowe) shifts his focus to field medicine, choosing to work primarily on an ambulance with his new partner, paramedic Rox (Moon Bloodgood). And Leanne (Marcia Gay Harden) begins her journey to adopt Ariel (Emily Alyn Lind). Moon Bloodgood joins the cast as Willis’ New Partner, Paramedic Rox.