While responding to a call of shots fired at a family residence, Lindsay (Sophia Bush) and Halstead (Jesse Lee Soffer) discover the only survivor is the youngest daughter who is traumatized. While Lindsay and Dr. Charles (guest star Oliver Platt) evaluate the girl and see if she can help identify the killer, Antonio (Jon Seda) and Olinsky (Elias Koteas) look into a pyramid scheme "selfhelp" group for potential suspects. Meanwhile, Platt (Amy Morton) tries to make the case to Commander Crowley (guest star Barbara Eve Harris) for Burgess (Marina Squerciati) and Roman (Brian Geraghty) to remain partners.
A little girl disappears from the ER; Addison and Jake butt heads over one of his patients; a new doctor starts at Saint Ambrose; Stephanie asks Sam about Addison.
As a new woman brings Sheldon happiness, he also becomes more suspicious about a patient's involvement in Sarah's disappearance.
When the CSIs investigate a triple homicide, Russell has to find a way to connect with a 6-year-old girl who was the sole survivor and witness. (TV-14 L, V)
The Knave is awakened by magic with the help of an unlikely ally and he goes in search of Alice only to find her in terrible danger, and Cyrus does his best to evade the Red Queen.
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