Nicole Cannon

House and the team take on the case of a high-profile fitness trainer who collapses while shooting an infomercial. As the team tests her for possible conditions such as exercise-induced asthma, steroid abuse or even a possible vitamin deficiency due to her strict diet, the patient’s condition continues to worsen. Though she touts herself as an all-natural fitness guru, the team soon discovers she has a slimming secret that may be contributing to her deteriorating condition. Meanwhile, Thirteen begins her participation in a clinical drug trial for Huntington’s disease led by Foreman, Kutner sets up and runs an online medical advice clinic under House’s name and Cuddy moves into House’s office while hers is being repaired, much to the dismay of her new officemate.

The team encounters a teenage boy who collapsed from severe pelvic pain after playing basketball. Tests reveal the boy has genetic mosaicism, or both male and female DNA, and the boy's parents inform House and the team that the boy is unaware of his condition. They consciously chose a gender for him when he was born and raised him accordingly, never telling him about his unique condition. However, when his condition worsens and his life is threatened, the parents wonder whether they made the right decision. Meanwhile, Cuddy and Wilson suspect something is wrong with House when he starts acting way too nicely. When they discover the shocking answer, they must face the prospect that House may be changed forever.

In the sixth season finale, a new lead in a cold case requires Lisbon to delay her plans to leave for Washington, D.C. with Marcus Pike, giving Jane time to finally come to terms with his feelings for her and decide on a course of action.

In Part One of a Two-Part crossover episode to conclude on "Without A Trace," a kidnap victim from New York who went missing six years ago may be the same boy whose death Grissom and the CSI team are investigating in Las Vegas. (TV-14)

The CSIs set out to track down a pedophile suspected of murdering an FBI agent's wife and kidnapping his children. (TV-14)