Patrick Price

House and the team take on the case of James Sidas, an exceptionally brilliant physicist and author who traded his successful career for a job as a courier. For the ailing patient, intelligence is a miserable burden that has prompted depression and addiction, and this, coupled with his myriad unusual symptoms, nearly stumps the team. Meanwhile, the doctors at Princeton Plainsboro wrestle with strained personal relationships.

The team treats an ailing groom; House, Chase and Foreman visit a karaoke bar during a raucous night out.

When the team treats a 6-year-old with multiple health issues, they must collaborate with her mother (Jessica Collins), who is also a doctor; Wilson and House go on vacation.

In the emotional series finale, directed by series creator and executive producer David Shore, treating a drug addict patient (guest star James LeGros, "Mildred Pierce") results in House examining his life, his future and his own personal demons.