Sarah Utterback

Derek and Meredith try (unsuccessfully) to be discreet after they spend the night together at Meredith's house, but their haggard appearance speaks volumes to everyone - including Bailey, who warns Meredith to end the relationship; George suspects an anesthesiologist of drinking on the job but is reluctant to speak up about it; Alex treats a former schoolmate who finds honor in self-mutilation; Izzie's boyfriend takes extreme measures in order for them to spend more time together; Cristina seems to be battling a case of the flu.

An outbreak of a sexually transmitted disease affects several members of the hospital staff, prompting Chief Webber to call a meeting, and the chief reluctantly confides to Derek about his own medical concerns; Izzie and Cristina are worried by a patient's wife and daughter who are at odds over his care; Burke treats Bill, a college buddy whose medical diagnosis raises some questions regarding his wife's actions; just as Meredith and Derek grow more intimate, a bombshell is dropped.

When a family arrives at Seattle Grace Hospital after a serious car accident, Alex learns that their injuries are only the beginning of their problems; as Dr. Webber recovers from brain surgery, it seems that his wife has some concerns about the state of their marriage.

The Thanksgiving holiday is more difficult for the interns and residents than any of them is willing to admit.

A man who has priapism comes to the hospital, and Meredith awkwardly realizes that he is her one-night stand.

Cristina Yang has little sympathy for an inmate (Rosanna Arquette), who jeopardizes her health to get out of solitary confinement.