As Dr. Ethan Choi (Brian Tee) treats a bleeding teenage girl, he discovers she's just given birth, sparking a frantic search for her abandoned baby. When the details of the teen's troubled past emerge, Ethan finds himself at odds with pediatrician Dr. Natalie Manning (Torrey DeVitto) and hospital administrator Sharon Goodwin (S. Epatha Merkerson) as they're forced to make some difficult decisions about the teen's future. Dr. Will Halstead (Nick Gehlfuss) treats a hypochondriac with chest pains while struggling to navigate his overbearing wife. Meanwhile, med student Sarah Reese (Rachel DiPillo) and psychiatrist Dr. Daniel Charles (Oliver Platt) treat a patient suffering from dementia, only to discover she may not have dementia at all.
Bravo Team sets out on a special ops mission to take down the financier and mastermind behind several terrorist attacks.
Michael dodges assassination attempts by a Czech assassin from his past while trying to rescue a friend’s daughter from a prostitution ring.
Dr. Halstead (Nick Gehlfuss) revives a "do-not-resuscitate" terminally ill cancer patient, and the repercussions prompt his quick removal from the case and a pending lawsuit against Chicago Med. A homeless man's arrival is passed down to April (Yaya DaCosta) and an uneager Dr. Reese (Rachel DiPillo), but the circumstances surrounding his short stay catch both off-guard. Following the assessment and treatment of a bi-polar patient with an unhealthy dependence for lithium, Dr. Choi's (Brian Tee) own personal issues come to the surface, prompting him to seek the advice of Dr. Charles (Oliver Platt). The medical staff is shocked to learn one of their own has life-threatening disease.
A new set of lungs could save his life through an innovative surgical procedure but an unforeseen medical problem arises with Ray that might derail the doctor's grand plans. Sarah (Rachel DiPillo) contemplates which hospital to select for her residency match while Maggie (Marlyne Barrett) and April (Yaya DaCosta) make their push for her to remain at Chicago Med. Meanwhile, Dr. Choi (Brian Tee) works to determine the cause of an injured teenage star hockey player with an overbearing father while Dr. Halstead (Nick Gehlfuss) and Dr. Manning (Torrey DeVitto) continue to clash.
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