Oscar-nominated actor John C. Reilly ("Chicago") portrays naive and socially awkward Dr. Steve Brule in this Adult Swim series that sees the doctor examining various parts of everyday life. As he discusses such ordinary topics as boats, animals and money, Brule reveals information about his personal life, some of which is shocking and disturbing. Brule is joined throughout the series by recurring characters, who offer the likes of movie reviews and news updates.