Cheyenne, Smitty and a woman they just rescued from an Indian attack are trapped by a band of desperados in their fortified mountain hideaway.

Trying to guide a lost wagon train, Cheyenne and Smitty tangle with a gang of cattle rustlers.

Cheyenne tries to help two prospectors in their search for a gold mine, but then they encounter renegade Indians who try to rob them.

Pursuing the bandits who killed a friend of theirs, Cheyenne and Smitty find that the gang has taken over an entire town and only the local padre has the courage to stand against them.

Cheyenne's previous acquaintance with a woman involves him in blackmail and nearly gets him killed.

Cheyenne has his troubles keeping a prisoner alive: the man is accused of murder and townspeople want him hanged---now!