Stand-up star Dane Cook and three fellow comics--Jay Davis, Robert 'Bobby' Kelly and Gary Gulman--set out on a customized bus from Burbank, CA (destination: Boston, MA) on a 30-day, 20-gig, sold-out 'Tourgasm' of America. Highlights include: a rib-crunching scooter fall that nearly sidelines the headliner for the premier show at Sonoma State University; the first of many heated arguments between Jay and Bobby, this time over the fact that Jay won't join in the group's porn chats; a fish-tossing diversion with cutting consequences for Gary; and a trip up the Space Needle in Seattle before hitting the stage at Washington State University on Day 3.

Outside Bozeman, Montana, on Day 5, the comedy posse saddles up at a dude ranch. Next stop is New Orleans (pre-Katrina), where Jay tests out a new joke at Tulane University, to decidedly mixed results. Later, Dane and Bobby figure out how to lose a couple of female suitors on Bourbon Street.

Dane's latest malady (a nasty cold), combined with a Madison Square Garden commitment, detours him from Chicago to New York for a quick visit with his doctor. The multiple-medication therapy works wonders--but will Dane make it back to Central Michigan University in time for the gig? On Day 12, Bobby follows Dane to the doctor in Kalamazoo, and the boys play ice hockey before a show at Western Michigan U. Later, in Cincinnati, Dane pouts after losing a go-cart race to Bobby, but recovers when his girlfriend arrives for some TLC before a Day 13 gig at Xavier.

Day 15. Dane and the guys arrive at Kent State University (Ohio) for Tourgasm's first show without Gary, who is rumored to be in L.A. with his girlfriend. Despite Gary's absence, not to mention Bobby and Jay's backstage bickering, the show is a killer, with Dane getting a standing ovation on a rock-concert scale. The next day, heading towards Syracuse, NY, the boys play a game of garment-tossing at Niagara Falls, then pair off for the 'Campground Gravel Pit Bowl'--a heated touch-football game that ends with Bobby in the hospital with a badly injured knee. Will he be able to continue performing? Only time will tell.

Despite concerns about his injured leg and limited mobility, Bobby performs at Syracuse University. The tour then winds its way through New York City and Philadelphia, where a clueless van driver nearly causes the boys to miss a live TV appearance. In Baltimore, Gary relives one of his darkest moments: last night's heckle-ridden show. The bad vibes are only slightly mitigated by a 45-minute trip to a crab restaurant, where the consensus is that the meat just wasn't worth the work. Dane shows off his internet acumen to Jay, then spearheads a Terrapin prank on the injury-prone Bobby, who's been at the dentist after shattering a tooth on a crab shell. The boys' luck turns in University Park, PA, where they play the tour's biggest gig to some 7,500 raucous Penn State fans. Afterwards, Dane admits that this was one of those highlights when he can say 'I've made it.'

In Charlottesville, VA, the boys compete in a game of indoor paintball that ends with the ultracompetitive Dane accusing Jay of foul play. Later, Dane's dizzy spell fuels speculation that the show at the University of Virginia will be cancelled, but Gary's 'perfect' set, combined with the crowd's overwhelming support, pull the star through. Dane's competitive juices flow again during a heated poker game, followed by an exhilarating white-water rafting trip near Richmond. The tour then heads north to familiar territory: Massachusetts, where some frenetic 'original' fans at Fitchburg College welcome home their comedic hero.