After the mysterious brutal attack of a local college co-ed, Portland homicide Detective Nick Burkhardt (David Giuntoli) discovered he is descendant of an elite line of criminal profilers known as "Grimms," charged with keeping balance between humanity and the mythological creatures of the world. As he tries to hide the dangers of his new found calling from his fiancé, Juliette Silverton (Bitsie Tulloch), and his partner, Hank Griffin (Russell Hornsby), he becomes ever more entrenched in the ancient rivalries and alliances of the Grimm world. With help from his reluctant confidant, Monroe (Silas Weir Mitchell), a reformed Grimm creature himself, Nick must navigate through the forces of a larger-than-life mythology. Reggie Lee and Sasha Roiz also star.

A case of breaking and entering introduces Nick (David Giuntoli) and Hank (Russell Hornsby) to a mysterious family whose cultural background blurs the line of right and wrong. Meanwhile, Nick tasks Monroe (Silas Weir Mitchell) with safeguarding Aunt Marie (guest star Kate Burton). Bitsie Tulloch, Sasha Roiz and Reggie Lee also star.

The station is abuzz as Nick (David Giuntoli) and Hank (Russell Hornsby) are called to a case where an innocent flash mob results in a gruesome homicide. As Nick delves further into the investigation, he learns more about his unique family history, and finds himself at odds when he and Hank are assigned to protect a dark character from his recent past. Bitsie Tulloch, Silas Weir Mitchell, Sasha Roiz and Reggie Lee also star.

After investigating a strange cluster of female deaths and disappearances, Nick (David Giuntoli) sends Monroe (Silas Weir Mitchell) undercover to get a whiff of a hypnotic suspect. In the meantime, a stranger shows up looking to avenge the death of his friend at the hands of a Grimm, but he’ll have to get past Captain Renard (Sasha Roiz). Russell Hornsby, Bitsie Tulloch and Reggie Lee also star.

Nick (David Giuntoli) and Hank's (Russell Hornsby) investigation of a dead high school teacher leads them to the school's outcast, Roddy. Nick realizes that there's more to Roddy than meets the eye, and enlists Monroe's (Silas Weir Mitchell) help to get through to the troubled teenager before he exacts revenge on the students who wronged him. Meanwhile, Nick learns that his presence is beginning to affect the creature world. Bitsie Tulloch, Sasha Roiz and Reggie Lee also star.

Nick (David Giuntoli) is called to a suspected arson case, which exposes a longstanding family feud that brings Monroe (Silas Weir Mitchell) face-to-face with characters from his troubled past. While Monroe wrestles with restraining his wild side, it’s up to Nick to keep everything from going up in flames. Russell Hornsby, Bitsie Tulloch, Sasha Roiz and Reggie Lee also star.