Immortal thief Amanda is followed by detectives Nick Wolfe and Claudia Hoffmann (Torri Higginson). Meanwhile, rogue detective Stanley Ferris (James Purcell) kills her fence, Immortal Basil Morgan (Julian Richings), and frames her. When Morgan fetches Amanda at the police station, he recognizes Ferris as his murderer. Ferris tries to kill Wolfe, who is saved by Amanda. Ferris then goes for Amanda, but Hoffmann dies in her place. Ferris shoots Amanda and is killed by Wolfe. Wolfe witnesses Amanda resurrecting.

Wolfe and Amanda cannot prevent Navajo code talker Walter (James Kidnie) from being killed by Immortal Mario Cardoza (Carlo Rota). Amanda helped Cardoza in 1952 and Walter found evidence of them being still alive. Wolfe works this out. Amanda admits her immortality to him. Cardoza kills himself by paying a hitman in order to disappear. The plan works, but Amanda finally beheads Cardoza.

Wolfe kills Morgan Kenworth (Cedric Smith), an assassin whose target was media proprietor Denise Grady (Carolyn Dunn). Wolfe realizes Kenworth is Immortal. Amanda recalls how Denise Grady's ancestor killed Kenworth's son in 1897 and realizes Kenworth kills the best of the Gradys of every generation. Despite Amanda's warnings, Wolfe fights Kenworth, who is beheaded by a falling shard of glass.

Myers asks Wolfe to retrieve top secret plans at the Romanian embassy. Amanda agrees to help to escape Immortal Stefan Collier (James Kee). Amanda and Wolfe's attempted robbery is foiled by both Collier and enemy agent Martha Anonesuc (Tara Rosling), who takes the plans and flees to the nearest airport. Amanda and Wolfe follow and stop Anonesuc. Amanda finally fights Collier.

FBI agents Martin Foster (Chuck Shamata) and Hewlitt (Frank Pellegrino) kill a scientist. His father, Charlie (Lawrence Dane), asks Amanda and Wolfe for help. After they find genetically modified seeds in another dead scientist's house, they are arrested by FBI. Foster bails them out to get the seeds, but they reveal the story to the press. Foster walks free after his trial and is killed by Charlie, who is killed by Hewlitt.

Simon Clark (Philip Akin) and Riley Del Deegan (John Ralston) steal the jewels of the Maria Rose wreckage. Amanda had helped two freed slaves to get on board the Maria Rose in 1720. Clark, descendant of the freed slaves, wants the deed that freed his ancestors and kills Del Deegan who refuses to retrieve it. A dying Clark asks Amanda for help, and Amanda and Wolfe steal the deed for his children.