Two teams of best friends enter the Pepperdome with confidence, but Chef Willie's demonic sauces bring them down hard and early. Does either team have what it takes to mount a comeback from the very bottom of their stomachs?

In this battle of the sexes, two teams duke it out against the catastrophic concoctions from Chef Willie. One will extinguish the fires and take home $25,000 while the other goes down in flames! And it all goes down in the Pepperdome!

Two comic book guys take on two twerkin’ besties! The Constrictor Sauce knocks the comic book guys to their knees, but they continue to fight for $25,000! Can their will be enough to stop their opponents from twerking their way to victory?

Fiery identical twins take on saucy drag queens in the Pepperdome. It's duke it out or puke it out in this episode where one player becomes very intimate with the Hot Ones spit bucket.

Cocky sisters challenge best bros in the Pepperdome. But the sauce proves too hot to handle for one team, resulting in the first-ever TKO.

Gym-loving ladies power through the pain while bartending besties try to knock back the heat. But the fight for $25,000 won't be an easy one. Friendships will strain, people will cry, and stomachs will be destroyed in the Pepperdome!