A case turns personal for Pride when the body of a Petty Officer is identified as a former gang member he once mentored. Meanwhile, Brody continues her search for the perfect place to call home in New Orleans. David McCallum guest stars as Doctor Donald "Ducky" Mallard; Steven Weber guest stars as Councilman Douglas Hamilton; and James McDaniel guest stars as Papa Parks.

NCIS Special Agent Tony DiNozzo assists the New Orleans team when a Navy lieutenant on liberty dies of the bubonic plague. The team races to locate all additional sailors on liberty, control a potential outbreak and determine the source of the highly infectious disease. NCIS stars Michael Weatherly, Rocky Carroll and Pauley Perrette guest star.

The NCIS team investigates the crash of an armored transport bus carrying Naval brig detainees after four prisoners escape, including a black market broker who is one of the country's biggest national security threats. Meanwhile, Pride turns to Gibbs for assistance when a case file needed for the investigation is full of redactions. NCIS stars Mark Harmon and Rocky Carroll guest star.

After a Navy SEAL is found murdered in a sorority house, the NCIS team must determine if the motive pertained to one of his classified missions or collegiate foul play. Meanwhile, Pride's daughter, Laurel, pays the NCIS office a visit. Shanley Caswell stars as Pride's daughter, Laurel.

The NCIS team is given a 22-hour deadline after the murder investigation of a Chief Warrant Officer who specialized in counterintelligence reveals his wife had been kidnapped and is being held for ransom. Meanwhile, Senior FBI Agent Fornell travels to the Big Easy to assist with the case. 

With New Orleans decorated for Halloween, the NCIS team investigates the murder of a Naval Staff Judge Advocate found in a cemetery dressed in a Victorian costume with vampiric puncture wounds on her neck. Meanwhile, the team debates what Halloween night activity and costumes would be best. Paige Turco and Steven Weber guest star.