SAINTS & STRANGERS is a docudrama about the events during and after the voyage of the Pilgrims on the Mayflower to the New World. It shows the efforts of the cargo ship's passengers, including William Bradford (Vincent Kartheiser), John Carver (Ron Livingston), Myles Standish (Michael Jibson), John Billington (Brian F. O'Byrne), Edward Winslow (Barry Sloane), and Steven Hopkins (Ray Stevenson), to keep themselves and their families, including Dorothy Bradford (Anna Camp) and Elizabeth Hopkins (Natascha McElhone), alive in order to establish a British colony in Virginia. But when the ship lands on the coast of what is now known as Massachusetts, they face starvation, illness, and native tribes, including the Wampanoag, the Narraganset, and the Nauset, that can't agree on how to contend with their arrival. As Massasoit Osamequin, Yellow Feather (Raoul Trujillo), and his prize warrior Hobbamock (Tatanka Means) attempt to establish peaceful relations with the English settlers with the help of their Patuxet translator, Squanto (Kalani Queypo), the Pilgrims and the Native Americans struggle to understand each other and to establish the balance of power between them.