In a cramped New Jersey motel room, eight shots ring out and two construction workers lay dead. There are no witnesses and no apparent motive, but police do uncover one key piece of evidence which puts police on the trail of a heartless killer.

A 15-year old girl in a race for her life is savagely beaten and killed in an Ohio cemetery. To catch this killer forensic experts must do the impossible: come up with a DNA sample when none exists.

Nineteen-year-old college student, Jodi Sanderholm never vanishes, and there are no clues. Jodi's dance team, provides a crucial name in the investigation, and the entire case hinges on a single arm hair that may crack the case.

The body of a missing man turns up in the scrub brush of Lone Star cattle country - at least some of it does. The entire case depends on a toxicologist whose never worked a murder case before. Everyone is surprised by what she finds.

The Columbia Rive Gorge is the pristine setting for a bone-crushing car accident, involving evidence that doesn't add up. When a doctor examines the young victim, the mystery only deepens.

In a quiet Mississippi River town, a 55-year old civil war buff vanishes into thin air. Months later and hundreds of miles away a skull is found buried in cement at a truck stop, and another mystery unfolds.