Determined not to compromise her career or cool reputation to the clichés of motherhood, Reagan Brinkley (Christina Applegate) adjusts to life with a baby and returns to work with the support of her stay-at-home husband, Chris (Will Arnett). As if motherhood weren't enough, as a talk-show executive producer, Reagan must also tend to the endless needs of her friend and boss Ava (Maya Rudolph), an ambitious but vulnerable talk-show host. Nick Cannon stars as Ava's charismatic co-host Calvin and Jennifer Hall stars as Ava's long-suffering assistant Missy. Matt Lauer guest stars.

When a "cool" new couple moves in across the street, Reagan (Christina Applegate) and Chris (Will Arnett) become obsessed with finding out every detail about them. Elsewhere, Ava (Maya Rudolph) struggles with the fact that baby Amy does not like her, especially when she takes a liking to Calvin (Nick Cannon). Jennifer Hall also stars.

Chris (Will Arnett) tries to get Reagan (Christina Applegate) to bring the sexy back into their relationship with some advice from his new friend Reed (guest star Will Forte, "Saturday Night Live"). Meanwhile, when Ava (Maya Rudolph) finds out her ex-boyfriend, B-Ro (guest star Jorma Taccone, "Saturday Night Live," The Lonely Island), is getting married, she blames Reagan for the advice she gave her that caused them to break up.

Reagan's (Christina Applegate) love for online shopping takes a bizarre turn when she and Chris (Will Arnett) go on the hunt for a practical family car. Concerned about their newborn's welfare, Chris aims to negotiate a deal for the perfect new car that is safe but not boring. Meanwhile, Ava (Maya Rudolph) decides to take on more serious talk show topics, but is overwhelmed by the amount of preparation it takes to pull it off. Nick Cannon and Jennifer Hall also star.

Reagan (Christina Applegate) fears that her busy schedule may be affecting her parenting skills. Chris (Will Arnett) finds a new calling in Amy's playgroup. Meanwhile, Ava (Maya Rudolph) continues to struggle with the lack of quality time she has with Reagan. Jennifer Hall also stars.

Reagan (Christina Applegate) tries to keep it together when her "perfect"; birth plan falls apart, while Chris (Will Arnett) wrestles with the decision to leave his law firm. Elsewhere, Ava (Maya Rudolph) must overcome the fears that are keeping her away from her best friend at such an important time. Nick Cannon and Jennifer Hall also star.