The Hauntley family has just moved from their home in Transylvania to a neighborhood in Pennsylvania to open a business. Vampirina, or Vee, and her family are friendly vampires and her parents, Oaxana and Boris Hauntley have opened a Bed & Breakfast for their visiting guests; ghouls and goblins! Vee is the new kid in town and must face the trials, tribulations, and joys of fitting in with her very human classmates. She learns how to look past other's differences to the piece that makes each individual special with the help of her best friend and next-door neighbor Poppy and close friend Bridget.