Jackson Oz, a young renegade American zoologist living in Africa, discovers a link between strange animal attacks on people occurring around the world and his late father's controversial theories about an impending threat to the human race. Meanwhile, journalist Jamie Campbell and veterinary pathologist Mitch Morgan team up to investigate similar abnormal animal behavior in Los Angeles.

After Jackson Oz rescues his best friend, Abraham Kenyatta, from a lion attack in Botswana, Abraham's firsthand account of the attack reveals that the lions are no longer afraid of humans and might be killing for sport. Also, Jamie and Mitch run tests on a lion cub in the Los Angeles Zoo and uncover a link to a chemical made by a biotechnology company, and Chloe Tousignant returns to Paris where she must overcome her own trauma and focus on her work as a government intelligence analyst.

Jackson Oz and Abraham Kenyatta fly to Japan to recover the rest of Oz's father's research involving animals. Also, Jamie convinces Mitch to accompany her on a trip to her hometown in Louisiana to show a senator their findings on the abnormal behavior of the zoo lions. In Paris, Chloe is the first to be recruited by a shadowy intelligence agent, Gaspard Alves (Henri Lubatti), who is looking for the cause of the strange animal behavior, and a death row inmate escapes from a Mississippi prison after a vicious wolf invasion sets the prison ablaze.

Jackson, Abraham, Mitch, Jamie and Chloe are tasked by a top intelligence agent to find the cause of the strange animal behavior around the world. When the team travels to Mississippi to investigate the wolf attack on the prison, Mitch and Abraham break off to catch one of the wolves, and Chloe, Jackson and Jamie discover that death row inmate escapee Evan Lee Hartley (Marcus Hester) might somehow be involved in the attack. Also, the team meets FBI Agent Ben Shafer (Geoff Stults), who may know more about the prison fire than he's saying.

Jackson, Jamie and Agent Shaffer search for a chemist in Alabama who has evidence of Reiden Global's role in the growing animal problem. Meanwhile, Chloe, Mitch and Abraham fly to Rio de Janeiro to delay the local government's plan for a massive bat extermination and come up against a ruthless drug lord.

While searching for a solution to the bat problem in Rio de Janeiro, Mitch and Chloe are kidnapped by the local drug lord and Abraham must come to the rescue. Also, reeling from the car crash that allowed escaped death row inmate Evan Lee Hartley to steal the one piece of evidence they had against Reiden Global, the Mother Cell, Jamie, Jackson and Agent Shaffer team up to track him down and lands Jamie in trouble with the FBI.