After a brain injury, Chief of Internal Medicine Dr. Amy Larsen fights to rebuild her life and career, forging a new path despite the obstacles ahead.

While at the hospital recovering, Amy can't help but insert herself into her roommate's case.

Amy, allowed to return to work under very strict guidelines, teams up with TJ to treat a patient suffering from mysterious liver problems; Sonya and Jake help an elderly couple navigate the final chapter of their love story.

Amy must confront who she became after the tragedy struck her family seven years ago.

Amy and Sonya endeavor to help a teen in need of a bone marrow transplant and his brother whose own health issues jeopardize disability to donate; Jake deals with a fainting bride and her worried groom; Michael struggles with a secret.

Amy and Jake try to uncover the cause of a unique patient's worsening condition.