Jessi Klein was born in New York City. Following graduation from Vassar College, Klein pursued a career as a comedian, writer, and producer of comic television. She began her career with production roles behind the scenes of acclaimed comedy series like "Strangers with Candy" (Comedy Central 1999-2000) and "Chapelle's Show" (Comedy Central 2003-06), and soon graduated to a position in the writer's room on shows like "The Showbiz Show with David Spade" (Comedy Central 2005-07), "Samantha Who?" (ABC 2007-09), eventually on "Saturday Night Live" (NBC 1975-). From there on out, she went on to serve as writer and producer on hit series like "Inside Amy Schumer" (Comedy Central 2013-16) and "Transparent" (Amazon 2014-19). After channeling her experiences with adolescence into the book You'll Grow Out of It (2016), she went on to lend her insights to the like-themed animated comedy series "Big Mouth" (Netflix 2017-), co-created by Nick Kroll, Andrew Goldberg, Mark Levin, and Jennifer Flackett. On the series, for which Klein served as a consulting producer, she voiced the main character Jessi Glaser, a teenaged girl dealing with the stresses of adolescence, including her parents' divorce.