A new patient in critical need of a heart transplant must rely on the care of Dr Panttiere and her unconventional methods.

An ethical debate arises when Alex suggests performing risky surgery on conjoined twins diagnosed with cancer; Alex questions her relationship with Pierce.

Alex believes that the arrival of a young man, who is only able to speak sentences backwards, is an opportunity to test some new technology, but Millicent disagrees.

Alex makes a risky move when she tries to find volunteers for an experimental cancer treatment; Max wants to change the family dynamic with Alex; Ji-Sung and Callahan connect.

A patient questions Alex's ability to leave personal grief outside the OR when she performs heart surgery on the anniversary of her sister's death; Millicent dates an artist; Pierce wants to be a bigger part of Alex's family.

Alex, Jesse, and Millicent fight to save a former heart transplant patient when she sustains life-threatening injuries in a car crash.