Wayne Wolfe Jr. discovers his grandfather was the serial killer Edward Wayne Edwards and teams up with retired detective John Cameron; they examine Edwards as a suspect in various murder cases including The Zodiac and JonBenet Ramsey.

Wayne and John head to San Francisco where they examine Edwards' involvement in one of the most chilling unsolved cases in American history, the Zodiac murders; Wayne visits his relatives to find out more about his grandfather.

John Cameron has a theory that Edwards was capable of killing children, including having a hand in the child beauty queen JonBenet Ramsey murder and the Atlanta Child Murders; Wayne learns about the murder of Ed's foster son, Dannie Boy Edwards.

Edwards, a successful family man, preaches about being a reformed criminal while hiding his nature as a murderous con man who may have killed union leader Jimmy Hoffa in 1975 and framed Steven Avery for the murder of Teresa Halbach in 2002.

The guys examine the origins of Edwards becoming a serial killer; Ed's mother died when he was a toddler and John has a theory that he relived the experience of her death by killing brunettes like Laci Peterson and the Black Dahlia.

John has come under fire for his theories and Wayne has reached a breaking point trying to understand his own past; they investigate Edwards' connection to one of the most notorious unsolved murders in Oregon history.