Noah, Ethan, Jack, and New Michael, better known as the comedy troupe Asperger's Are Us, kick off their challenging six-week tour across the United States with a performance in Boston for an enthusiastic hometown crowd.

The troupe arrives in New York City for a date at the legendary comedy venue Caroline's. When the show proves difficult and some routines fall flat, the guys question whether the tour was a good idea and hope for a better outcome in Baltimore.

Noah, Ethan, Jack and New Michael spend the night at a caravan park before dealing with unexpected audience feedback in North Carolina; New Michael vexes the other guys by deciding to drink during a show in Tennessee.

The troupe goes sightseeing in Chicago before travelling to Cincinnati, where a challenging show quickly spins out of control; Noah returns to his hometown of Dayton; the guys do a show that promises to get them back on track.

With a week left to go in the tour, Ethan begins to doubt himself and the purpose of the group's cross-country journey; with their worst caravan issues yet, the guys fight to make it on time to a show in Seattle, where Noah's dad is due to attend.

As their six-week tour comes to an end, Noah, Ethan, Jack and New Michael prepare for a final show in Los Angeles and reflect on their experiences, bidding goodbye to their temperamental caravan and a whirlwind life on the road.