Stephen's jaw cancer is a cause for critical concern. For surgeons Prav Praveen and Sat Parmar, there simply isn't a moment to lose. They need to urgently perform an extraordinary and radical procedure - removing and discarding Stephen's jaw.

Follows a liver transport, an operation to remove a rare cancer of the soft palette and a particularly nasty open fracture of a woman's lower leg.

If surgeons don't operate on Pratyush soon, his tumour could push him into a coma, before killing him; Mariella needs a ground-breaking procedure for a recurring bowel cancer.

When 29-year-old Laura is diagnosed with an incurable brain tumour, she must undergo a risky surgery in order to extend her life. However, the surgery may have a drastic effect on her memory and can be fatal.

Presents a risky operation on a 66-year-old's massive aortic aneurism, a complicated procedure to remove an angiosarcoma and an operation which carries a risk of facial paralysis.

Gary has a rare tumour in his spine. Leaving it in place will probably lead to paralysis, but an operation carries a huge risk; Margaret develops a hole in her skull.