When Nadine's father comes to town for her birthday, Devon enlists help to ensure that he makes the best first impression; Red Rock decides to cut the entire OBGYN department; Nic cares for a teenage patient whose condition is deteriorating.
A renowned paediatric cardiac surgeon proves unfit for surgery; a Dolly Parton drag queen collapses on stage; Nic and Conrad suspect a patient may be the victim of sex trafficking; Nadine delivers some surprising news to Devon.
Conrad finds himself caught between his duties as a doctor and his loyalty to Kit when he discovers that her son-in-law may be suffering from a serious disease; Devon and Nic make a shocking discovery about a former patient.
Cain recruits Ezra to help keep an emergency situation under wraps; Nic works to come up with a support system for a patient in need of a lung transplant; Kit's son-in-law's condition continues to worsen.
Just when Derek's condition seems to be improving, a severe complication arises; when Cain's former girlfriend is admitted to the hospital for surgery, the doctors finally get a glimpse into his personal life.
After a long wait, Conrad and Nic prepare for their wedding day; flashbacks to the early days of the COVID-19 crisis shine a light on the heroism of the doctors and the toll the virus took on everyone at Chastain Memorial.
When Cain's elective surgery patient returns with complications, Mina and Raptor butt heads over how to handle the situation; Conrad and Devon treat a local Congresswoman.
When Cain tries to be a hero at a crash scene, he is struck by a car, causing Chastain's doctors to put aside their personal issues to try and save his life.
The staff work together to diagnose a mother-daughter pair who both come in with a mystery illness; Devon deals with an unexpected visit from his mother; Conrad and Nic try to figure out the best time to tell everyone their big news.
With Chastain on the verge of shutting down due to the sale by Red Rock, Conrad tries a last-ditch effort to save the hospital; the doctors plan for their next career moves; Nic is injured by a deranged patient.
As Nic struggles with her recovery, a former colleague comes back to the hospital to support her; the search begins for a new CEO; Devon sees an opportunity to fix the system.
Dr. Conrad Hawkins
Dr. Randolph Bell
Dr. Devon Pravesh
Dr. AJ Austin
Dr. Kit Voss
Dr. Barrett Cain
Dr. Leela Devi
Shaunette Renée Wilson
Dr. Mina Okafor
Dr. Lane Hunter
Amy Holden Jones
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