Using advanced psychological profiling, an FBI unit tries to locate a missing 28-year-old woman who was recently dumped by a married colleague. Last seen by her doorman on the night that she vanished, her apartment appears to be intact. Jack fears that she is lost forever, until a ransom note appears on her mother's email list demanding a million dollars for her safe return.

Jack and the team search for a boy that disappeared on a subway train en route to Yankee Stadium for a birthday celebration.

Jack and the team search for a woman who was whisked away in her own car while out shopping with her husband. It soon becomes apparent that the case is more than a random kidnapping.

The hunt is on for a woman that disappeared without anybody really noticing she was gone; a man holds out hope that Jack can locate his long-missing son.

The team search for a 17-year-old boy who was last seen with the charismatic headmaster of his private boarding school, and with whom he may have had an unsavoury relationship.

Jack and the team search for New York businessman Patrick Kent, who disappears after he checks-in for a routine flight home. During the investigation, the agents are shocked to discover that Kent has been leading a secret double life, and that his father-in-law, Noah Ridder, has him under surveillance by a private investigator for another reason entirely.