A team assembles to investigate the case of Evaristo J. Salas, a 16-year-old given a 30-year sentence for a crime he is adamant he did not commit.

Investigators Ira Todd and Joe Kennedy speak to the lead detective on the Salas case, who claims an informant implicated Evaristo, but when the informant comes forward, the team are shocked by what they learn.

On July 16, 1996, Bertha Tardy and three of her employees were murdered. Curtis Flowers was later arrested and went on to be tried six times over 21 years. Currently he faces a possible seventh trial, while continuing to maintain his innocence.

Curtis Flowers is convicted of a quadruple murder. After 21 years of prosecutions, six trials, and questionable tactics by the State of Mississippi, it is wondered if it is possible to determine Flowers' guilt or innocence.

A team of experts and an Idaho investigator look into Christopher Tapp's claim that he was coerced into a false confession over the brutal 1993 murder of Angie Dodge in Idaho Falls.

The investigative team looks for a killer on the loose, hoping to exonerate Christopher Tapp who is serving time. Then after two decades a surprise offer by the prosecution comes Tapp's way.