Moreno stayed with Vitagraph, off and on, through 1923, appearing in more than 100 films. As onstage, he provided masculine support to such stars as the Talmadge sisters, Lillian Walker and Muriel Ostriche, and starred in a number of action serials (i.e., "The Iron Test" 1918; "The Perils of Thunder Mountain" 1919; "The Invisible Hand" 1920). Moreno hated these films and decamped for Paramount in 1923. That studio made him a full-fledged star in such vehicles as "My American Wife" (1923), opposite Gloria Swanson, and "The Spanish Dancer" (also 1923), with Pola Negri. He spent the rest of his career free-lancing, and enjoyed many successes in the late silent era: the sea saga "Mare Nostrum" (1926), the Garbo vehicle "The Temptress" (also 1926), the delightful Clara Bow comedy "It" (1927), the British-made hit "Madame Pompadour" (1927) and the flapper comedy "Synthetic Sin" (1928). Talkies put an end to Moreno's top-flight stardom, but he was never out of work. He did Spanish-language versions of many American films and journeyed to Mexico and Cuba to both star and direct. He helmed Mexico's first two talking films, "Santa" and "Aguilas Frente al Sol" (both 1932). In later years, Moreno appeared in character roles in such films as "Notorious" (1946), "The Captain from Castille" (1947) and "The Searchers" (1956). He also played the scientist who discovered "The Creature from the Black Lagoon" (1954). Wealthy and bored with films, Moreno retired in 1958, dying in 1967 after several years of ill health.