After a suspected serial killer wakes up from a coma, the BAU reopens the case to determine if he really doesn't remember the crimes.
Cuddy receives news that forces her to re-evaluate her priorities; a teenage patient's suspicious body scars suggest his illness is more than physical.
Michael seeks revenge against Whistler and Gretchen and uncovers unbelievable news; Lincoln and Michael are reunited with the gang and get an offer from a Homeland Security agent; Mahone experiences a devastating loss; T-Bag is deserted.
Kelly becomes a cheerleader to win the attention of a football star.
Jake's return to Jericho after a long absence coincides with a deadly explosion that catapults residents into chaos, as they wonder whether they are the only people left alive.