The crew of a lone naval ship try to save humanity when they discover a deadly virus has wiped out most of the population.
The crew members arrive at the Guantanamo Bay military base to collect food, fuel and medical supplies. When they come under attack by escaped Gitmo prisoners, they team up with a gruff private contractor to push back against the offensive.
Chandler's leadership is put to the test when the ship's propulsion system is in danger of breaking down, the crew becomes overworked and exhausted, and Dr. Scott could potentially lose all of her research on the virus.
A mission to help Rachel with her vaccine trials leads Chandler and a small team into the jungles of Nicaragua, where they tangle with a former drug kingpin who will stop at nothing to maintain his power over his oppressed society.
A distress call near Jamaica is received. Chandler and a small team stage a rescue mission, only to fall victim to a surprise attack that leaves Chandler and Tex stranded at sea.