An attack on Jim Brass kicks off a twisted conspiracy targeting the Las Vegas crime lab.
Grissom and Sara close in on who framed Hodges; a cargo plane lands autonomously at McCarran Airport and everyone on board is dead.
Max puts CSI on lockdown when evidence in a new murder tips Grissom and Sara to a new suspect in the crime lab; Folsom and Allie investigate a series of chilling killings at a dilapidated clown-themed hotel.
Facing an existential threat that could bring down the crime lab, a brilliant new team of forensic investigators welcomes back old friends and deploys new techniques to preserve and serve justice in Sin City.
When David Hodges goes missing, the CSI team searches for any piece of evidence that can help locate him, clear his name and save the reputation of the crime lab.