A man (Zeljko Ivanek) willing to kill or die for a diagnosis takes House, Thirteen and a number of patients hostage in Cuddy's office, where House tries to come up with the correct diagnosis.
A distinguished senator asks Gibbs for help in solving the murder of a young female Naval officer.
The Charmed Ones do not realize that baby Wyatt's new imaginary friend is actually the demon Vicus, who is trying to win Wyatt's trust to convert him to evil.
When an unidentified body is found inside a crushed car, the team must extract the bones to identify the victim and find the killer.
The investigation of two teens leads Don and his team to a counterfeiting ring.